3S0N
Crystal Structure of Human Chymase with Benzimidazolone Inhibitor
Summary for 3S0N
Entry DOI | 10.2210/pdb3s0n/pdb |
Descriptor | Chymase, 2-acetamido-2-deoxy-beta-D-glucopyranose, ZINC ION, ... (5 entities in total) |
Functional Keywords | serine protease, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor |
Biological source | Homo sapiens (human) |
Total number of polymer chains | 1 |
Total formula weight | 25880.14 |
Authors | Qian, K.C.,Farrow, N.A.,Padyana, A.K. (deposition date: 2011-05-13, release date: 2011-07-20, Last modification date: 2024-10-09) |
Primary citation | Lo, H.Y.,Nemoto, P.A.,Kim, J.M.,Hao, M.H.,Qian, K.C.,Farrow, N.A.,Albaugh, D.R.,Fowler, D.M.,Schneiderman, R.D.,Michael August, E.,Martin, L.,Hill-Drzewi, M.,Pullen, S.S.,Takahashi, H.,De Lombaert, S. Benzimidazolone as potent chymase inhibitor: Modulation of reactive metabolite formation in the hydrophobic (P(1)) region. Bioorg.Med.Chem.Lett., 21:4533-4539, 2011 Cited by PubMed: 21733690DOI: 10.1016/j.bmcl.2011.05.126 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.95 Å) |
Structure validation
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