3RHK
Crystal structure of the catalytic domain of c-Met kinase in complex with ARQ 197
Summary for 3RHK
Entry DOI | 10.2210/pdb3rhk/pdb |
Descriptor | Hepatocyte growth factor receptor, 1-[(3R,4R)-4-(1H-indol-3-yl)-2,5-dioxopyrrolidin-3-yl]pyrrolo[3,2,1-ij]quinolinium (3 entities in total) |
Functional Keywords | kinase, receptor tyrosine kinase, transferase-transferase inhibitor complex, transferase/transferase inhibitor |
Biological source | Homo sapiens (human) |
Cellular location | Membrane; Single-pass type I membrane protein: P08581 |
Total number of polymer chains | 2 |
Total formula weight | 72714.05 |
Authors | Eathiraj, S.,Palma, R.,Volckova, E.,Hirschi, M.,France, D.S.,Ashwell, M.A.,Chan, T.C. (deposition date: 2011-04-11, release date: 2011-04-27, Last modification date: 2024-02-21) |
Primary citation | Eathiraj, S.,Palma, R.,Volckova, E.,Hirschi, M.,France, D.S.,Ashwell, M.A.,Chan, T.C. Discovery of a novel mode of protein kinase inhibition characterized by the mechanism of inhibition of human mesenchymal-epithelial transition factor (c-Met) protein autophosphorylation by ARQ 197. J.Biol.Chem., 286:20666-20676, 2011 Cited by PubMed: 21454604DOI: 10.1074/jbc.M110.213801 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.94 Å) |
Structure validation
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