3RHK
Crystal structure of the catalytic domain of c-Met kinase in complex with ARQ 197
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A, B | Hepatocyte growth factor receptor | polymer | 318 | 35990.6 | 2 | UniProt (P08581) Pfam (PF07714) In PDB | Homo sapiens (human) | HGF receptor, HGF/SF receptor, Proto-oncogene c-Met, Scatter factor receptor, SF receptor, Tyrosine-protein kinase Met |
2 | A, B | 1-[(3R,4R)-4-(1H-indol-3-yl)-2,5-dioxopyrrolidin-3-yl]pyrrolo[3,2,1-ij]quinolinium | non-polymer | 366.4 | 2 | Chemie (M97) | |||
3 | water | water | 18.0 | 598 | Chemie (HOH) |
Sequence modifications
A, B: 1038 - 1346 (UniProt: P08581)
PDB | External Database | Details |
---|---|---|
Met 1029 | - | expression tag |
Gly 1030 | - | expression tag |
His 1031 | - | expression tag |
His 1032 | - | expression tag |
His 1033 | - | expression tag |
His 1034 | - | expression tag |
His 1035 | - | expression tag |
His 1036 | - | expression tag |
Met 1037 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 2 |
Total formula weight | 71981.3 | |
Non-Polymers* | Number of molecules | 2 |
Total formula weight | 732.8 | |
All* | Total formula weight | 72714.1 |