3RHK

Crystal structure of the catalytic domain of c-Met kinase in complex with ARQ 197

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B (A, B)	Hepatocyte growth factor receptor	polymer	318	35990.6	2	UniProt (P08581) Pfam (PF07714)	Homo sapiens (human)	HGF receptor, HGF/SF receptor, Proto-oncogene c-Met, Scatter factor receptor, SF receptor, Tyrosine-protein kinase Met
2	C, D (A, B)	1-[(3R,4R)-4-(1H-indol-3-yl)-2,5-dioxopyrrolidin-3-yl]pyrrolo[3,2,1-ij]quinolinium	non-polymer		366.4	2	Chemie (M97)
3	E, F (A, B)	water	water		18.0	598	Chemie (HOH)

Sequence modifications

A, B: 1038 - 1346 (UniProt: P08581)

PDB	External Database	Details
Met 1029	-	expression tag
Gly 1030	-	expression tag
His 1031	-	expression tag
His 1032	-	expression tag
His 1033	-	expression tag
His 1034	-	expression tag
His 1035	-	expression tag
His 1036	-	expression tag
Met 1037	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	71981.3
Non-Polymers*	Number of molecules	2
	Total formula weight	732.8
All*	Total formula weight	72714.1

*Water molecules are not included.