3RDH
X-ray induced covalent inhibition of 14-3-3
Summary for 3RDH
Entry DOI | 10.2210/pdb3rdh/pdb |
Descriptor | 14-3-3 protein zeta/delta, 4-[(E)-{4-formyl-5-hydroxy-6-methyl-3-[(phosphonooxy)methyl]pyridin-2-yl}diazenyl]benzoic acid, NICKEL (II) ION, ... (4 entities in total) |
Functional Keywords | phosphoser/thr-mimetic agent, phosphoserine/threonine-recognition protein, signaling protein-inhibitor complex, signaling protein/inhibitor |
Biological source | Homo sapiens (human) |
Cellular location | Cytoplasm: P63104 |
Total number of polymer chains | 4 |
Total formula weight | 114053.29 |
Authors | Horton, J.R.,Upadhyay, A.K.,Fu, H.,Cheng, X. (deposition date: 2011-04-01, release date: 2011-09-28, Last modification date: 2023-09-13) |
Primary citation | Zhao, J.,Du, Y.,Horton, J.R.,Upadhyay, A.K.,Lou, B.,Bai, Y.,Zhang, X.,Du, L.,Li, M.,Wang, B.,Zhang, L.,Barbieri, J.T.,Khuri, F.R.,Cheng, X.,Fu, H. Discovery and structural characterization of a small molecule 14-3-3 protein-protein interaction inhibitor. Proc.Natl.Acad.Sci.USA, 108:16212-16216, 2011 Cited by PubMed: 21908710DOI: 10.1073/pnas.1100012108 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.39 Å) |
Structure validation
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