3R8I
Crystal Structure of PPARgamma with an achiral ureidofibrate derivative (RT86)
Summary for 3R8I
Entry DOI | 10.2210/pdb3r8i/pdb |
Related | 2I4J 2I4P 2I4Z |
Descriptor | Peroxisome proliferator-activated receptor gamma, 2-(4-{2-[1,3-benzoxazol-2-yl(heptyl)amino]ethyl}phenoxy)-2-methylpropanoic acid (3 entities in total) |
Functional Keywords | protein-dna complex, bundle of alpha-helices, small four-stranded beta-sheet, transcription, activator, diabetes mellitus, obesity, transcription regulation, dna binding, phosphorylation, nucleus |
Biological source | Homo sapiens (human) |
Cellular location | Nucleus: P37231 |
Total number of polymer chains | 2 |
Total formula weight | 65826.21 |
Authors | Pochetti, G.,Montanari, R.,Loiodice, F.,Laghezza, A.,Fracchiolla, G.,Lavecchia, A.,Novellino, E.,Crestani, M. (deposition date: 2011-03-24, release date: 2012-01-11, Last modification date: 2023-09-13) |
Primary citation | Porcelli, L.,Gilardi, F.,Laghezza, A.,Piemontese, L.,Mitro, N.,Azzariti, A.,Altieri, F.,Cervoni, L.,Fracchiolla, G.,Giudici, M.,Guerrini, U.,Lavecchia, A.,Montanari, R.,Di Giovanni, C.,Paradiso, A.,Pochetti, G.,Simone, G.M.,Tortorella, P.,Crestani, M.,Loiodice, F. Synthesis, characterization and biological evaluation of ureidofibrate-like derivatives endowed with peroxisome proliferator-activated receptor activity. J.Med.Chem., 55:37-54, 2012 Cited by PubMed: 22081932DOI: 10.1021/jm201306q PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.3 Å) |
Structure validation
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