3QVF

Crystal structure of fosfomycin resistance kinase FomA from Streptomyces wedmorensis complexed with MgADP and fosfomycin vanadate

Summary for 3QVF

Entry DOI	10.2210/pdb3qvf/pdb
Related	3D40 3D41 3QUN 3QUO 3QUR 3QVH
Descriptor	FomA protein, ADENOSINE-5'-DIPHOSPHATE, dihydroxy{[(2R,3S)-3-methyloxiran-2-yl]phosphonato-kappaO}oxovanadium, ... (5 entities in total)
Functional Keywords	fosfomycin, antibiotic resistance, phosphoryl transfer, kinase, transferase
Biological source	Streptomyces wedmorensis
Total number of polymer chains	1
Total formula weight	31566.37
Authors	Pakhomova, S.,Bartlett, S.G.,Doerner, P.A.,Newcomer, M.E. (deposition date: 2011-02-25, release date: 2011-07-20, Last modification date: 2023-09-13)
Primary citation	Pakhomova, S.,Bartlett, S.G.,Doerner, P.A.,Newcomer, M.E. Structural and biochemical insights into the mechanism of fosfomycin phosphorylation by fosfomycin resistance kinase FomA. Biochemistry, 50:6909-6919, 2011 Cited by PubMed: 21728358 DOI: 10.1021/bi2004334 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.85 Å)

Structure validation