3QP0

HIV-1 protease (mutant Q7K L33I L63I) in complex with a novel inhibitor

Summary for 3QP0

• Entry DOI: 10.2210/pdb3qp0/pdb
• Related: 3QIH 3QN8
• Descriptor: Protease, CHLORIDE ION, (4aS,7aS)-1,4-bis[3-(hydroxymethyl)benzyl]hexahydro-1H-pyrrolo[3,4-b]pyrazine-2,3-dione, ... (4 entities in total)
• Functional Keywords: aspartyl protease, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
• Biological source: Human immunodeficiency virus type 1 (BRU ISOLATE) (HIV-1)
• Cellular location: Matrix protein p17: Virion (Potential). Capsid protein p24: Virion (Potential). Nucleocapsid protein p7: Virion (Potential). Reverse transcriptase/ribonuclease H: Virion (Potential). Integrase: Virion (Potential): P03367
• Total number of polymer chains: 2
• Total formula weight: 22111.43

Authors

Lindemann, I.,Heine, A.,Klebe, G. (deposition date: 2011-02-11, release date: 2012-02-15, Last modification date: 2023-11-01)

• Primary citation: Lindemann, I.,Klee, N.,Heine, A.,Diederich, W.E.,Klebe, G.; Novel inhibitors for HIV-1 protease; To be Published,

Experimental method

X-RAY DIFFRACTION (1.45 Å)