3QMK
Crystal structure of the E2 domain of APLP1 in complex with heparin hexasaccharide
Summary for 3QMK
Entry DOI | 10.2210/pdb3qmk/pdb |
Descriptor | Amyloid-like protein 1, 2-O-sulfo-alpha-L-idopyranuronic acid-(1-4)-2-deoxy-6-O-sulfo-2-(sulfoamino)-alpha-D-glucopyranose-(1-4)-2-O-sulfo-alpha-L-idopyranuronic acid-(1-4)-2-deoxy-6-O-sulfo-2-(sulfoamino)-alpha-D-glucopyranose, SULFATE ION, ... (4 entities in total) |
Functional Keywords | app, alzheimer's disease, cellular adhesion, heparin, brain, cell adhesion |
Biological source | Homo sapiens (human) |
Cellular location | Cell membrane; Single-pass type I membrane protein. C30: Cytoplasm: P51693 |
Total number of polymer chains | 2 |
Total formula weight | 51137.16 |
Authors | |
Primary citation | Xue, Y.,Lee, S.,Ha, Y. Crystal structure of amyloid precursor-like protein 1 and heparin complex suggests a dual role of heparin in E2 dimerization. Proc.Natl.Acad.Sci.USA, 108:16229-16234, 2011 Cited by PubMed: 21930949DOI: 10.1073/pnas.1103407108 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.21 Å) |
Structure validation
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