5T1Z
Estrogen Receptor Alpha Ligand Binding Domain Y537S Mutant in Complex with Ethoxytriphenylethylene and GRIP Peptide
Replaces: 3Q97Summary for 5T1Z
Entry DOI | 10.2210/pdb5t1z/pdb |
Descriptor | Estrogen receptor, Nuclear receptor coactivator 2, 4,4'-[(1Z)-1-(4-ethoxyphenyl)but-1-ene-1,2-diyl]diphenol, ... (4 entities in total) |
Functional Keywords | estrogen receptor, angular estrogen, breast cancer, agonist, estrogenic, apoptosis, transcription |
Biological source | Homo sapiens (Human) More |
Total number of polymer chains | 4 |
Total formula weight | 60817.66 |
Authors | Fanning, S.W.,Rajan, S.S.,Maximov, P.Y.,Abderrahman, B.H.,Surojeet, S.,Fernandes, D.J.,Fan, P.,Curpan, R.F.,Greene, G.L.,Jordan, V.C. (deposition date: 2016-08-22, release date: 2017-08-30, Last modification date: 2023-10-04) |
Primary citation | Maximov, P.Y.,Abderrahman, B.,Fanning, S.W.,Sengupta, S.,Fan, P.,Curpan, R.F.,Rincon, D.M.Q.,Greenland, J.A.,Rajan, S.S.,Greene, G.L.,Jordan, V.C. Endoxifen, 4-Hydroxytamoxifen and an Estrogenic Derivative Modulate Estrogen Receptor Complex Mediated Apoptosis in Breast Cancer. Mol. Pharmacol., 94:812-822, 2018 Cited by PubMed: 29739819DOI: 10.1124/mol.117.111385 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.102 Å) |
Structure validation
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