5T1Z

Estrogen Receptor Alpha Ligand Binding Domain Y537S Mutant in Complex with Ethoxytriphenylethylene and GRIP Peptide

Replaces:  3Q97

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B (A, B)	Estrogen receptor	polymer	250	28468.5	2	UniProt (P03372) Pfam (PF00104)	Homo sapiens (Human)	ER,ER-alpha,Estradiol receptor,Nuclear receptor subfamily 3 group A member 1
2	C, D (C, D)	Nuclear receptor coactivator 2	polymer	13	1579.9	2	UniProt (Q15596)	Homo sapiens	NCoA-2,Class E basic helix-loop-helix protein 75,bHLHe75,Transcriptional intermediary factor 2,hTIF2
3	E, F (A, B)	4,4'-[(1Z)-1-(4-ethoxyphenyl)but-1-ene-1,2-diyl]diphenol	non-polymer		360.4	2	Chemie (Q97)
4	G, H, I, J (A, B, C, D)	water	water		18.0	143	Chemie (HOH)

Sequence modifications

A, B: 305 - 554 (UniProt: P03372)

PDB	External Database	Details
Met 381	Cys 381	conflict
Ser 537	Tyr 537	engineered mutation

Contents of the asymmetric unit

Polymers	Number of chains	4
	Total formula weight	60096.8
Non-Polymers*	Number of molecules	2
	Total formula weight	720.9
All*	Total formula weight	60817.7

*Water molecules are not included.