3Q61
3'-Fluoro Hexitol Nucleic Acid DNA Structure
Summary for 3Q61
Entry DOI | 10.2210/pdb3q61/pdb |
Descriptor | DNA (5'-D(*GP*CP*GP*TP*AP*(F3H)P*AP*CP*GP*C)-3') (2 entities in total) |
Functional Keywords | a-form dna, 3'-fluoro hexitol nucleic acid, fhna, antisense oligonucleotides, dna |
Total number of polymer chains | 2 |
Total formula weight | 6154.05 |
Authors | Seth, P.R.,Allerson, C.R.,Prakash, T.P.,Siwkowski, A.,Berdeja, A.,Yu, J.,Pallan, P.S.,Watt, A.T.,Gaus, H.,Bhat, B.,Egli, M.,Swayze, E.E. (deposition date: 2010-12-30, release date: 2012-01-18, Last modification date: 2023-09-13) |
Primary citation | Egli, M.,Pallan, P.S.,Allerson, C.R.,Prakash, T.P.,Berdeja, A.,Yu, J.,Lee, S.,Watt, A.,Gaus, H.,Bhat, B.,Swayze, E.E.,Seth, P.P. Synthesis, improved antisense activity and structural rationale for the divergent RNA affinities of 3'-fluoro hexitol nucleic acid (FHNA and Ara-FHNA) modified oligonucleotides. J.Am.Chem.Soc., 133:16642-16649, 2011 Cited by PubMed: 21919455DOI: 10.1021/ja207086x PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.56 Å) |
Structure validation
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