3PUP
Structure of Glycogen Synthase Kinase 3 beta (GSK3B) in complex with a ruthenium octasporine ligand (OS1)
Summary for 3PUP
Entry DOI | 10.2210/pdb3pup/pdb |
Descriptor | Glycogen synthase kinase-3 beta, Ruthenium octasporine (2 entities in total) |
Functional Keywords | wnt signaling pathway, serine/threonine-protein kinase, ruthenium glycogen synthase kinase picomolar, nucleotide-binding, kinase, transferase, atp-binding, phosphoprotein |
Biological source | Homo sapiens (human) |
Cellular location | Cytoplasm: P49841 |
Total number of polymer chains | 2 |
Total formula weight | 94748.32 |
Authors | Filippakopoulos, P.,Kraling, K.,Essen, L.O.,Meggers, E.,Knapp, S. (deposition date: 2010-12-06, release date: 2010-12-22, Last modification date: 2023-09-06) |
Primary citation | Feng, L.,Geisselbrecht, Y.,Blanck, S.,Wilbuer, A.,Atilla-Gokcumen, G.E.,Filippakopoulos, P.,Kraling, K.,Celik, M.A.,Harms, K.,Maksimoska, J.,Marmorstein, R.,Frenking, G.,Knapp, S.,Essen, L.O.,Meggers, E. Structurally sophisticated octahedral metal complexes as highly selective protein kinase inhibitors. J.Am.Chem.Soc., 133:5976-5986, 2011 Cited by PubMed: 21446733DOI: 10.1021/ja1112996 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.99 Å) |
Structure validation
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