3PS1
Crystal structure of the Escherichia Coli LPXC/LPC-011 complex
Summary for 3PS1
Entry DOI | 10.2210/pdb3ps1/pdb |
Related | 3PS2 3PS3 |
Descriptor | UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase, ZINC ION, 4-[4-(4-aminophenyl)buta-1,3-diyn-1-yl]-N-[(2S,3R)-3-hydroxy-1-(hydroxyamino)-1-oxobutan-2-yl]benzamide, ... (7 entities in total) |
Functional Keywords | hydrolase, deacetylation, antibiotic, acyl udp-glcnac, hydroxamate, lpc-011, baab sandwich, lipid a biosynthesis, lipid a synthesis, hydrolase-antibiotic complex, hydrolase/antibiotic |
Biological source | Escherichia coli IHE3034 |
Total number of polymer chains | 1 |
Total formula weight | 34431.60 |
Authors | Lee, C.-J.,Zhou, P. (deposition date: 2010-11-30, release date: 2011-01-19, Last modification date: 2024-02-21) |
Primary citation | Liang, X.,Lee, C.J.,Chen, X.,Chung, H.S.,Zeng, D.,Raetz, C.R.,Li, Y.,Zhou, P.,Toone, E.J. Syntheses, structures and antibiotic activities of LpxC inhibitors based on the diacetylene scaffold. Bioorg.Med.Chem., 19:852-860, 2011 Cited by PubMed: 21194954DOI: 10.1016/j.bmc.2010.12.017 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.85 Å) |
Structure validation
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