3PA8

Structure of the C. difficile TcdB cysteine protease domain in complex with a peptide inhibitor

Summary for 3PA8

Entry DOI	10.2210/pdb3pa8/pdb
Related PRD ID	PRD_000971
Descriptor	Toxin B, N-acetylglycyl-N-[(3S)-1-hydroxy-5-methyl-2-oxohexan-3-yl]-L-serinamide, CALCIUM ION, ... (6 entities in total)
Functional Keywords	clan cd cysteine protease, protease, toxin, toxin-peptide inhibitor complex, toxin/peptide inhibitor
Biological source	Clostridium difficile
Total number of polymer chains	2
Total formula weight	59877.68
Authors	Lupardus, P.J.,Garcia, K.C. (deposition date: 2010-10-18, release date: 2010-12-15, Last modification date: 2023-09-06)
Primary citation	Puri, A.W.,Lupardus, P.J.,Deu, E.,Albrow, V.E.,Garcia, K.C.,Bogyo, M.,Shen, A. Rational design of inhibitors and activity-based probes targeting Clostridium difficile virulence factor TcdB. Chem.Biol., 17:1201-1211, 2010 Cited by PubMed: 21095570 DOI: 10.1016/j.chembiol.2010.09.011 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2 Å)

Structure validation