3P8O
Crystal structure of HCV NS3/NS4A protease complexed with des-bromine analogue of BI 201335
Summary for 3P8O
Entry DOI | 10.2210/pdb3p8o/pdb |
Related | 3P8N |
Related PRD ID | PRD_000849 |
Descriptor | HCV serine protease NS3, HCV non-structural protein 4A, SODIUM ION, ... (5 entities in total) |
Functional Keywords | hepatitis c virus, ns3, ns4a, halogen bond, serine protease, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor |
Biological source | Hepatitis C virus (HCV) |
Cellular location | Core protein p21: Host endoplasmic reticulum membrane ; Single-pass membrane protein . Core protein p19: Virion . Envelope glycoprotein E1: Virion membrane ; Single-pass type I membrane protein . Envelope glycoprotein E2: Virion membrane ; Single-pass type I membrane protein . p7: Host endoplasmic reticulum membrane ; Multi-pass membrane protein . Protease NS2-3: Host endoplasmic reticulum membrane ; Multi-pass membrane protein . Serine protease NS3: Host endoplasmic reticulum membrane ; Peripheral membrane protein . Non-structural protein 4A: Host endoplasmic reticulum membrane ; Single-pass type I membrane protein . Non-structural protein 4B: Host endoplasmic reticulum membrane ; Multi-pass membrane protein . Non-structural protein 5A: Host endoplasmic reticulum membrane; Peripheral membrane protein. RNA-directed RNA polymerase: Host endoplasmic reticulum membrane ; Single-pass type I membrane protein : P26662 |
Total number of polymer chains | 4 |
Total formula weight | 44585.65 |
Authors | Lemke, C.T. (deposition date: 2010-10-14, release date: 2011-01-26, Last modification date: 2017-11-08) |
Primary citation | Lemke, C.T.,Goudreau, N.,Zhao, S.,Hucke, O.,Thibeault, D.,Llinas-Brunet, M.,White, P.W. Combined X-ray, NMR, and kinetic analyses reveal uncommon binding characteristics of the hepatitis C virus NS3-NS4A protease inhibitor BI 201335. J.Biol.Chem., 286:11434-11443, 2011 Cited by PubMed: 21270126DOI: 10.1074/jbc.M110.211417 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.3 Å) |
Structure validation
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