3P7G

Structure of the human Langerin carbohydrate recognition domain in complex with mannose

Replaces:  3BC7

Summary for 3P7G

• Entry DOI: 10.2210/pdb3p7g/pdb
• Related: 3P7F 3P7H
• Descriptor: C-type lectin domain family 4 member K, CALCIUM ION, alpha-D-mannopyranose, ... (4 entities in total)
• Functional Keywords: c-type lectin, membrane protein, glycoprotein, langerin, dc-sign, carbohydrate binding protein, calcium binding, sugar binding, immune system, langerhans cells, cd207
• Biological source: Homo sapiens (human)
• Cellular location: Membrane ; Single-pass type II membrane protein : Q9UJ71
• Total number of polymer chains: 4
• Total formula weight: 68291.47

Authors

Skerra, A.,Schiefner, A. (deposition date: 2010-10-12, release date: 2010-11-03, Last modification date: 2020-07-29)

• Primary citation: Chatwell, L.,Holla, A.,Kaufer, B.B.,Skerra, A.; The carbohydrate recognition domain of Langerin reveals high structural similarity with the one of DC-SIGN but an additional, calcium-independent sugar-binding site.; Mol.Immunol., 45:1981-1994, 2008; PubMed: 18061677; DOI: 10.1016/j.molimm.2007.10.030

Experimental method

X-RAY DIFFRACTION (1.5 Å)