3P5O
Crystal Structure of the First Bromodomain of Human Brd4 in complex with IBET inhibitor
Summary for 3P5O
Entry DOI | 10.2210/pdb3p5o/pdb |
Descriptor | Bromodomain-containing protein 4, 2-[(4S)-6-(4-chlorophenyl)-8-methoxy-1-methyl-4H-[1,2,4]triazolo[4,3-a][1,4]benzodiazepin-4-yl]-N-ethylacetamide, 1,2-ETHANEDIOL, ... (4 entities in total) |
Functional Keywords | brd4, bromodomain containing protein 4, antagonist, ibet, inhibition of acetylated lysine histone binding, transcription regulator, signaling protein-inhibitor complex, signaling protein/inhibitor |
Biological source | Homo sapiens (human) |
Cellular location | Nucleus (By similarity): O60885 |
Total number of polymer chains | 1 |
Total formula weight | 15771.55 |
Authors | Chung, C. (deposition date: 2010-10-09, release date: 2010-11-17, Last modification date: 2023-11-01) |
Primary citation | Nicodeme, E.,Jeffrey, K.L.,Schaefer, U.,Beinke, S.,Dewell, S.,Chung, C.,Chandwani, R.,Marazzi, I.,Wilson, P.,Coste, H.,White, J.,Kirilovsky, J.,Rice, C.M.,Lora, J.M.,Prinjha, R.K.,Lee, K.,Tarakhovsky, A. Suppression of inflammation by a synthetic histone mimic Nature, 468:1119-1123, 2010 Cited by PubMed: 21068722DOI: 10.1038/nature09589 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.6 Å) |
Structure validation
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