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3P5O

Crystal Structure of the First Bromodomain of Human Brd4 in complex with IBET inhibitor

Entity
Entity IDChain IDDescriptionTypeChain lengthFormula weightNumber of moleculesDB Name (Accession)Biological sourceDescriptive keywords
1A
(A)
Bromodomain-containing protein 4polymer12715099.41UniProt (O60885)
Pfam (PF00439)
Homo sapiens (human)Protein HUNK1
2B
(A)
2-[(4S)-6-(4-chlorophenyl)-8-methoxy-1-methyl-4H-[1,2,4]triazolo[4,3-a][1,4]benzodiazepin-4-yl]-N-ethylacetamidenon-polymer423.91Chemie (EAM)
3C, D, E, F
(A)
1,2-ETHANEDIOLnon-polymer62.14Chemie (EDO)
4G
(A)
waterwater18.0264Chemie (HOH)
Sequence modifications
A: 44 - 168 (UniProt: O60885)
PDBExternal DatabaseDetails
Ser 42-expression tag
Met 43-expression tag
Sequence viewer
Contents of the asymmetric unit
PolymersNumber of chains1
Total formula weight15099.4
Non-Polymers*Number of molecules5
Total formula weight672.2
All*Total formula weight15771.5
*Water molecules are not included.

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PDB entries from 2024-11-06

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