3P1D

Crystal structure of the bromodomain of human CREBBP in complex with N-Methyl-2-pyrrolidone (NMP)

Summary for 3P1D

Entry DOI	10.2210/pdb3p1d/pdb
Related	3P1C 3P1E 3P1F
Descriptor	CREB-binding protein, THIOCYANATE ION, 1-methylpyrrolidin-2-one, ... (5 entities in total)
Functional Keywords	structural genomics consortium, sgc, cbp, crebbp, creb binding protein isoform a, kat3a, rsts, rst, bromodomain, transcription
Biological source	Homo sapiens (human)
Cellular location	Cytoplasm: Q92793
Total number of polymer chains	2
Total formula weight	28742.14
Authors	Filippakopoulos, P.,Picaud, S.,Feletar, I.,Fedorov, O.,Muniz, J.,von Delft, F.,Arrowsmith, C.H.,Edwards, A.M.,Weigelt, J.,Bountra, C.,Knapp, S.,Structural Genomics Consortium (SGC) (deposition date: 2010-09-30, release date: 2010-11-24, Last modification date: 2023-09-06)
Primary citation	Filippakopoulos, P.,Picaud, S.,Mangos, M.,Keates, T.,Lambert, J.P.,Barsyte-Lovejoy, D.,Felletar, I.,Volkmer, R.,Muller, S.,Pawson, T.,Gingras, A.C.,Arrowsmith, C.H.,Knapp, S. Histone recognition and large-scale structural analysis of the human bromodomain family. Cell(Cambridge,Mass.), 149:214-231, 2012 Cited by PubMed: 22464331 DOI: 10.1016/j.cell.2012.02.013 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.86 Å)

Structure validation