3OXZ
Crystal structure of ABL kinase domain bound with a DFG-out inhibitor AP24534
Summary for 3OXZ
Entry DOI | 10.2210/pdb3oxz/pdb |
Related | 3IK3 3OY3 |
Descriptor | Tyrosine-protein kinase ABL1, 3-(imidazo[1,2-b]pyridazin-3-ylethynyl)-4-methyl-N-{4-[(4-methylpiperazin-1-yl)methyl]-3-(trifluoromethyl)phenyl}benzam ide (3 entities in total) |
Functional Keywords | protein-inhibitor complex, protein kinase two-domain fold, phosphotransferase, atp binding, phosphorylation, transferase-transferase inhibitor complex, transferase/transferase inhibitor |
Biological source | Mus musculus (mouse) |
Cellular location | Cytoplasm, cytoskeleton: P00520 |
Total number of polymer chains | 1 |
Total formula weight | 33330.00 |
Authors | Zhou, T.,Huang, W.S.,Wang, Y.,Thomas, M.,Keats, J.,Xu, Q.,Rivera, V.,Shakespeare, W.C.,Clackson, T.,Dalgarno, D.C.,Zhu, X. (deposition date: 2010-09-22, release date: 2010-12-15, Last modification date: 2023-09-06) |
Primary citation | Zhou, T.,Commodore, L.,Huang, W.S.,Wang, Y.,Thomas, M.,Keats, J.,Xu, Q.,Rivera, V.M.,Shakespeare, W.C.,Clackson, T.,Dalgarno, D.C.,Zhu, X. Structural Mechanism of the Pan-BCR-ABL Inhibitor Ponatinib (AP24534): Lessons for Overcoming Kinase Inhibitor Resistance. Chem.Biol.Drug Des., 77:1-11, 2011 Cited by PubMed: 21118377DOI: 10.1111/j.1747-0285.2010.01054.x PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.2 Å) |
Structure validation
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