3OXZ
Crystal structure of ABL kinase domain bound with a DFG-out inhibitor AP24534
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A | Tyrosine-protein kinase ABL1 | polymer | 284 | 32797.4 | 1 | UniProt (P00520) Pfam (PF07714) In PDB | Mus musculus (mouse) | Abelson murine leukemia viral oncogene homolog 1, Proto-oncogene c-Abl, p150 |
2 | A | 3-(imidazo[1,2-b]pyridazin-3-ylethynyl)-4-methyl-N-{4-[(4-methylpiperazin-1-yl)methyl]-3-(trifluoromethyl)phenyl}benzam ide | non-polymer | 532.6 | 1 | Chemie (0LI) | |||
3 | water | water | 18.0 | 89 | Chemie (HOH) |
Sequence modifications
A: 229 - 511 (UniProt: P00520)
PDB | External Database | Details |
---|---|---|
Gly 228 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 1 |
Total formula weight | 32797.4 | |
Non-Polymers* | Number of molecules | 1 |
Total formula weight | 532.6 | |
All* | Total formula weight | 33330.0 |