3OWD
Crystal Structure of HSP90 with N-Aryl-benzimidazolone II
Summary for 3OWD
Entry DOI | 10.2210/pdb3owd/pdb |
Related | 3OW6 3OWB |
Descriptor | Heat shock protein HSP 90-alpha, N-{[1-(5-chloro-2,4-dihydroxyphenyl)-2-oxo-2,3-dihydro-1H-benzimidazol-5-yl]methyl}naphthalene-1-sulfonamide (3 entities in total) |
Functional Keywords | hsp90, chaperone |
Biological source | Homo sapiens (human) |
Cellular location | Cytoplasm: P07900 |
Total number of polymer chains | 1 |
Total formula weight | 23644.19 |
Authors | Park, C.H. (deposition date: 2010-09-17, release date: 2011-09-21, Last modification date: 2024-02-21) |
Primary citation | Bruncko, M.,Tahir, S.K.,Song, X.,Chen, J.,Ding, H.,Huth, J.R.,Jin, S.,Judge, R.A.,Madar, D.J.,Park, C.H.,Park, C.M.,Petros, A.M.,Tse, C.,Rosenberg, S.H.,Elmore, S.W. N-aryl-benzimidazolones as novel small molecule HSP90 inhibitors. Bioorg.Med.Chem.Lett., 20:7503-7506, 2010 Cited by PubMed: 21106457DOI: 10.1016/j.bmcl.2010.10.010 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.63 Å) |
Structure validation
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