3OPM
Crystal Structure of Human DPP4 Bound to TAK-294
Summary for 3OPM
Entry DOI | 10.2210/pdb3opm/pdb |
Related | 3O95 3O9V |
Descriptor | Dipeptidyl peptidase 4, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-{[3-(aminomethyl)-2-(2-methylpropyl)-1-oxo-4-phenyl-1,2-dihydroisoquinolin-6-yl]oxy}acetamide, ... (5 entities in total) |
Functional Keywords | protease and 8-bladed beta-propeller domain, aminopeptidase, cell membrane, glycoprotein, hydrolase, membrane, protease, secreted, serine protease, signal-anchor, transmembrane, signaling protein, hydrolase-hydrolase inhibitor, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor |
Biological source | Homo sapiens (human) |
Total number of polymer chains | 4 |
Total formula weight | 348364.11 |
Authors | Yano, J.K.,Aertgeerts, K. (deposition date: 2010-09-01, release date: 2011-10-19, Last modification date: 2020-07-29) |
Primary citation | Banno, Y.,Miyamoto, Y.,Sasaki, M.,Oi, S.,Asakawa, T.,Kataoka, O.,Takeuchi, K.,Suzuki, N.,Ikedo, K.,Kosaka, T.,Tsubotani, S.,Tani, A.,Funami, M.,Tawada, M.,Yamamoto, Y.,Aertgeerts, K.,Yano, J.,Maezaki, H. Identification of 3-aminomethyl-1,2-dihydro-4-phenyl-1-isoquinolones: a new class of potent, selective, and orally active non-peptide dipeptidyl peptidase IV inhibitors that form a unique interaction with Lys554. Bioorg.Med.Chem., 19:4953-4970, 2011 Cited by PubMed: 21764322DOI: 10.1016/j.bmc.2011.06.059 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.72 Å) |
Structure validation
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