3OIV
H-RasG12V with allosteric switch in the "off" state
Summary for 3OIV
| Entry DOI | 10.2210/pdb3oiv/pdb |
| Related | 3OIU 3OIW |
| Descriptor | GTPase HRas, PHOSPHOAMINOPHOSPHONIC ACID-GUANYLATE ESTER, CALCIUM ION, ... (6 entities in total) |
| Functional Keywords | oncogene gtp-binding nucleotide-binding, signaling protein |
| Biological source | Homo sapiens (human) |
| Cellular location | Cell membrane. Isoform 2: Nucleus: P01112 |
| Total number of polymer chains | 1 |
| Total formula weight | 19860.96 |
| Authors | Buhrman, G.,Mattos, C. (deposition date: 2010-08-20, release date: 2010-12-08, Last modification date: 2024-02-21) |
| Primary citation | Buhrman, G.,Kumar, V.S.,Cirit, M.,Haugh, J.M.,Mattos, C. Allosteric Modulation of Ras-GTP Is Linked to Signal Transduction through RAF Kinase. J.Biol.Chem., 286:3323-3331, 2011 Cited by PubMed: 21098031DOI: 10.1074/jbc.M110.193854 PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (1.837 Å) |
Structure validation
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