3OF8
Structural Basis for Reversible and Irreversible Inhibition of Human Cathepsin L by their Respective Dipeptidyl Glyoxal and Diazomethylketone Inhibitors
Summary for 3OF8
Entry DOI | 10.2210/pdb3of8/pdb |
Related | 3OF9 |
Related PRD ID | PRD_000782 |
Descriptor | Cathepsin L1, Nalpha-[(benzyloxy)carbonyl]-N-[(2S)-1-(4-tert-butoxyphenyl)-4-hydroxy-3-oxobutan-2-yl]-L-phenylalaninamide (3 entities in total) |
Functional Keywords | hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor |
Biological source | Homo sapiens (human) |
Total number of polymer chains | 1 |
Total formula weight | 24853.44 |
Authors | Shenoy, R.T.,Sivaraman, J. (deposition date: 2010-08-14, release date: 2010-12-08, Last modification date: 2023-09-06) |
Primary citation | Shenoy, R.T.,Sivaraman, J. Structural basis for reversible and irreversible inhibition of human cathepsin L by their respective dipeptidyl glyoxal and diazomethylketone inhibitors. J.Struct.Biol., 173:14-19, 2011 Cited by PubMed: 20850545DOI: 10.1016/j.jsb.2010.09.007 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.2 Å) |
Structure validation
Download full validation report