3O7V

Crystal Structure of human Hiwi1 (V361M) PAZ domain (residues 277-399) in complex with 14-mer RNA (12-bp + 2-nt overhang) containing 2'-OCH3 at its 3'-end

Summary for 3O7V

• Entry DOI: 10.2210/pdb3o7v/pdb
• Related: 3O3I 3O6E 3O7X
• Descriptor: Piwi-like protein 1, RNA (5'-R(*GP*CP*GP*AP*AP*UP*AP*UP*UP*CP*GP*CP*UP*(OMU))-3') (3 entities in total)
• Functional Keywords: piwi, rna silencing, pi-rna, hiwi1, hili, paz domain, rna binding protein, rna binding protein-rna complex, rna binding protein/rna
• Biological source: Homo sapiens (human); More
• Cellular location: Cytoplasm : Q96J94
• Total number of polymer chains: 2
• Total formula weight: 19142.83

Authors

Tian, Y.,Simanshu, D.K.,Ma, J.-B.,Patel, D.J. (deposition date: 2010-08-01, release date: 2011-01-12, Last modification date: 2017-11-08)

• Primary citation: Tian, Y.,Simanshu, D.K.,Ma, J.B.,Patel, D.J.; Inaugural Article: Structural basis for piRNA 2'-O-methylated 3'-end recognition by Piwi PAZ (Piwi/Argonaute/Zwille) domains.; Proc.Natl.Acad.Sci.USA, 108:903-910, 2011; PubMed: 21193640; DOI: 10.1073/pnas.1017762108

Experimental method

X-RAY DIFFRACTION (2.1 Å)