3NY4
Crystal Structure of BlaC-K73A bound with Cefamandole
Summary for 3NY4
Entry DOI | 10.2210/pdb3ny4/pdb |
Descriptor | Beta-lactamase, PHOSPHATE ION, (6R,7R)-7-{[(2R)-2-hydroxy-2-phenylacetyl]amino}-3-{[(1-methyl-1H-tetrazol-5-yl)sulfanyl]methyl}-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid, ... (4 entities in total) |
Functional Keywords | penicillin binding protein, beta-lactam complex, hydrolase-antibiotic complex, hydrolase/antibiotic |
Biological source | Mycobacterium tuberculosis |
Total number of polymer chains | 1 |
Total formula weight | 30622.11 |
Authors | Tremblay, L.W.,Blanchard, J.S. (deposition date: 2010-07-14, release date: 2010-11-24, Last modification date: 2024-02-21) |
Primary citation | Tremblay, L.W.,Xu, H.,Blanchard, J.S. Structures of the Michaelis Complex (1.2 A) and the Covalent Acyl Intermediate (2.0 A) of Cefamandole Bound in the Active Sites of the Mycobacterium tuberculosis beta-Lactamase K73A and E166A Mutants. Biochemistry, 49:9685-9687, 2010 Cited by PubMed: 20961112DOI: 10.1021/bi1015088 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.22 Å) |
Structure validation
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