3NJ4
Fluoro-neplanocin A in Human S-Adenosylhomocysteine Hydrolase
Summary for 3NJ4
Entry DOI | 10.2210/pdb3nj4/pdb |
Descriptor | Adenosylhomocysteinase, NICOTINAMIDE-ADENINE-DINUCLEOTIDE, (4S,5S)-4-(6-amino-9H-purin-9-yl)-3-fluoro-5-hydroxy-2-(hydroxymethyl)cyclopent-2-en-1-one, ... (4 entities in total) |
Functional Keywords | s-adenosylhomocystein, hydrolase, nad |
Biological source | Homo sapiens (human) |
Cellular location | Cytoplasm: P23526 |
Total number of polymer chains | 4 |
Total formula weight | 195991.52 |
Authors | Jeong, L.S.,Lee, K.M.,Hwang, K.Y.,Choi, S.,Heo, Y.S. (deposition date: 2010-06-17, release date: 2011-05-04, Last modification date: 2024-03-20) |
Primary citation | Lee, K.M.,Choi, W.J.,Lee, Y.,Lee, H.J.,Zhao, L.X.,Lee, H.W.,Park, J.G.,Kim, H.O.,Hwang, K.Y.,Heo, Y.S.,Choi, S.,Jeong, L.S. X-ray crystal structure and binding mode analysis of human S-adenosylhomocysteine hydrolase complexed with novel mechanism-based inhibitors, haloneplanocin A analogues. J.Med.Chem., 54:930-938, 2011 Cited by PubMed: 21226494DOI: 10.1021/jm1010836 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.5 Å) |
Structure validation
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