3NHN

Crystal structure of the SRC-family kinase HCK SH3-SH2-linker regulatory region

Summary for 3NHN

Entry DOI	10.2210/pdb3nhn/pdb
Descriptor	Tyrosine-protein kinase HCK (2 entities in total)
Functional Keywords	hck, sh3-sh2-linker, src family kinase, sfk, transferase
Biological source	Homo sapiens (human)
Cellular location	Isoform 1: Lysosome. Isoform 2: Cell membrane ; Lipid-anchor . Cytoplasmic vesicle, secretory vesicle: P08631
Total number of polymer chains	1
Total formula weight	22311.91
Authors	Alvarado, J.J.,Betts, L.,Moroco, J.A.,Smithgall, T.E.,Yeh, J.I. (deposition date: 2010-06-14, release date: 2010-09-01, Last modification date: 2023-09-06)
Primary citation	Alvarado, J.J.,Betts, L.,Moroco, J.A.,Smithgall, T.E.,Yeh, J.I. Crystal Structure of the Src Family Kinase Hck SH3-SH2 Linker Regulatory Region Supports an SH3-dominant Activation Mechanism. J.Biol.Chem., 285:35455-35461, 2010 Cited by PubMed: 20810664 DOI: 10.1074/jbc.M110.145102 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.61 Å)

Structure validation