3N8M
Crystal Structure of the Grb2 SH2 Domain in Complex with An Acyclic Ligand Having the Sequence pYVNVP
Summary for 3N8M
Entry DOI | 10.2210/pdb3n8m/pdb |
Related | 1BMB 1JYR 1TZE |
Descriptor | Growth factor receptor-bound protein 2, PEPTIDE, GLYCEROL, ... (4 entities in total) |
Functional Keywords | grb2 sh2 domain, ligand preorganization, macrocycles, macrocyclic ligands, protein binding-peptide complex, protein binding/peptide |
Biological source | Homo sapiens (human) |
Cellular location | Golgi apparatus (By similarity): P62993 |
Total number of polymer chains | 2 |
Total formula weight | 14632.47 |
Authors | Whiddon, B.B.,Clements, J.H.,Martin, S.F. (deposition date: 2010-05-28, release date: 2010-12-15, Last modification date: 2023-11-22) |
Primary citation | Delorbe, J.E.,Clements, J.H.,Whiddon, B.B.,Martin, S.F. Thermodynamic and Structural Effects of Macrocyclization as a Constraining Method in Protein-Ligand Interactions. ACS MED.CHEM.LETT., 1:448-452, 2010 Cited by PubMed: 21116482DOI: 10.1021/ml100142y PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2 Å) |
Structure validation
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