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3N8M

Crystal Structure of the Grb2 SH2 Domain in Complex with An Acyclic Ligand Having the Sequence pYVNVP

Summary for 3N8M
Entry DOI10.2210/pdb3n8m/pdb
Related1BMB 1JYR 1TZE
DescriptorGrowth factor receptor-bound protein 2, PEPTIDE, GLYCEROL, ... (4 entities in total)
Functional Keywordsgrb2 sh2 domain, ligand preorganization, macrocycles, macrocyclic ligands, protein binding-peptide complex, protein binding/peptide
Biological sourceHomo sapiens (human)
Cellular locationGolgi apparatus (By similarity): P62993
Total number of polymer chains2
Total formula weight14632.47
Authors
Whiddon, B.B.,Clements, J.H.,Martin, S.F. (deposition date: 2010-05-28, release date: 2010-12-15, Last modification date: 2023-11-22)
Primary citationDelorbe, J.E.,Clements, J.H.,Whiddon, B.B.,Martin, S.F.
Thermodynamic and Structural Effects of Macrocyclization as a Constraining Method in Protein-Ligand Interactions.
ACS MED.CHEM.LETT., 1:448-452, 2010
Cited by
PubMed: 21116482
DOI: 10.1021/ml100142y
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (2 Å)
Structure validation

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