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1TZE

SIGNAL TRANSDUCTION ADAPTOR GROWTH FACTOR, GRB2 SH2 DOMAIN COMPLEXED WITH PHOSPHOTYROSYL HEPTAPEPTIDE LYS-PRO-PHE-PTYR-VAL-ASN-VAL-NH2 (KFPPYVNC-NH2)

Summary for 1TZE
Entry DOI10.2210/pdb1tze/pdb
DescriptorGROWTH FACTOR RECEPTOR-BOUND PROTEIN 2, PHOSPHOTYROSYL HEPTAPEPTIDE LYS-PRO-PHE-PTYR-VAL-ASN-VAL-NH2 (3 entities in total)
Functional Keywordssignal transduction adaptor growth factor bound protein 2 (grb2) src homology 2 domain (sh2), phosphotyrosyl heptapeptic ligand, complex (signal transduction-peptide), complex (signal transduction-peptide) complex, complex (signal transduction/peptide)
Biological sourceHomo sapiens (human)
Total number of polymer chains2
Total formula weight12392.04
Authors
Rahuel, J.,Grutter, M.G. (deposition date: 1996-06-06, release date: 1997-07-07, Last modification date: 2011-11-16)
Primary citationRahuel, J.,Gay, B.,Erdmann, D.,Strauss, A.,Garcia-Echeverria, C.,Furet, P.,Caravatti, G.,Fretz, H.,Schoepfer, J.,Grutter, M.G.
Structural basis for specificity of Grb2-SH2 revealed by a novel ligand binding mode.
Nat.Struct.Biol., 3:586-589, 1996
Cited by
PubMed: 8673601
DOI: 10.1038/nsb0796-586
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (2.1 Å)
Structure validation

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