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3N7Y

Crystal Structure of the Grb2 SH2 Domain in Complex with a 20-Membered Macrocyclic Ligand Having the Sequence pYVNV

Summary for 3N7Y
Entry DOI10.2210/pdb3n7y/pdb
Related1BM2 3N84
DescriptorGrowth factor receptor-bound protein 2, 20-membered peptide-like macrocyclic ligand (3 entities in total)
Functional Keywordsligand preorganization, macrocycles, macrocyclic ligands, golgi apparatus, host-virus interaction, phosphoprotein, protein binding-peptide complex, protein binding/peptide
Biological sourceHomo sapiens (human)
Cellular locationGolgi apparatus (By similarity): P62993
Total number of polymer chains6
Total formula weight36443.23
Authors
Whiddon, B.B.,Clements, J.H.,Martin, S.F. (deposition date: 2010-05-27, release date: 2011-01-12, Last modification date: 2023-11-15)
Primary citationDelorbe, J.E.,Clements, J.H.,Whiddon, B.B.,Martin, S.F.
Thermodynamic and Structural Effects of Macrocyclization as a Constraining Method in Protein-Ligand Interactions.
ACS MED.CHEM.LETT., 1:448-452, 2010
Cited by
PubMed: 21116482
DOI: 10.1021/ml100142y
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (2.02 Å)
Structure validation

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