3N2Z

The Structure of Human Prolylcarboxypeptidase at 2.80 Angstroms Resolution

Summary for 3N2Z

• Entry DOI: 10.2210/pdb3n2z/pdb
• Related: 3JYH
• Descriptor: Lysosomal Pro-X carboxypeptidase, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose, ... (5 entities in total)
• Functional Keywords: alpha/beta hydrolase, prcp, serine carboxypeptidase, hydrolase
• Biological source: Homo sapiens (human)
• Cellular location: Lysosome: P42785
• Total number of polymer chains: 1
• Total formula weight: 51976.46

Authors

Soisson, S.M.,Patel, S.B.,Lumb, K.J.,Sharma, S. (deposition date: 2010-05-19, release date: 2010-07-07, Last modification date: 2024-10-16)

Primary citation

Soisson, S.M.,Patel, S.B.,Abeywickrema, P.D.,Bryne, N.J.,Diehl, R.E.,Hall, D.L.,Ford, R.E.,Reid, J.C.,Rickert, K.W.,Shipman, J.M.,Sharma, S.,Lumb, K.J.
Structural definition and substrate specificity of the S28 protease family: the crystal structure of human prolylcarboxypeptidase.
Bmc Struct.Biol., 10:16-16, 2010

PubMed Abstract: The unique S28 family of proteases is comprised of the carboxypeptidase PRCP and the aminopeptidase DPP7. The structural basis of the different substrate specificities of the two enzymes is not understood nor has the structure of the S28 fold been described.

PubMed: 20540760
DOI: 10.1186/1472-6807-10-16

Experimental method

X-RAY DIFFRACTION (2.79 Å)