3N0P

A mutant human Prolactin receptor antagonist H30A in complex with the extracellular domain of the human prolactin receptor

Summary for 3N0P

Entry DOI	10.2210/pdb3n0p/pdb
Related	3MZG 3N06 3NCB 3NCC 3NCE 3NCF
Descriptor	Prolactin, Prolactin receptor, SODIUM ION, ... (5 entities in total)
Functional Keywords	ph dependence, hematopoietic cytokine, hormone-hormone receptor complex, hormone/hormone receptor
Biological source	Homo sapiens (human) More
Cellular location	Secreted: P01236 Membrane; Single-pass type I membrane protein. Isoform 7: Secreted: P16471
Total number of polymer chains	2
Total formula weight	46275.08
Authors	Kulkarni, M.V.,Tettamanzi, M.C.,Murphy, J.W.,Keeler, C.,Myszka, D.G.,Chayen, N.E.,Lolis, E.J.,Hodsdon, M.E. (deposition date: 2010-05-14, release date: 2010-09-29, Last modification date: 2023-09-06)
Primary citation	Kulkarni, M.V.,Tettamanzi, M.C.,Murphy, J.W.,Keeler, C.,Myszka, D.G.,Chayen, N.E.,Lolis, E.J.,Hodsdon, M.E. Two Independent Histidines, One in Human Prolactin and One in Its Receptor, Are Critical for pH-dependent Receptor Recognition and Activation. J.Biol.Chem., 285:38524-38533, 2010 Cited by PubMed: 20889499 DOI: 10.1074/jbc.M110.172072 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.1 Å)

Structure validation