3MYJ

Human Class I MHC HLA-A2 in complex with the WT-1 (126-134) (R1Y) peptide variant.

Summary for 3MYJ

• Entry DOI: 10.2210/pdb3myj/pdb
• Related: 1TVB 3HPJ
• Descriptor: HLA class I histocompatibility antigen, A-2 alpha chain, Beta-2-microglobulin, Wilms tumor protein, ... (5 entities in total)
• Functional Keywords: wt-1 peptide, r1y mutation, nonapeptide, mhc class i, hla-a2, cancer vaccine, disulfide bond, glycoprotein, host-virus interaction, immune response, membrane, mhc i, phosphoprotein, transmembrane, disease mutation, glycation, immunoglobulin domain, pyrrolidone carboxylic acid, secreted, immune system
• Biological source: Homo sapiens (human); More
• Cellular location: Membrane; Single-pass type I membrane protein: P01892; Secreted . Note=(Microbial infection) In the presence of M: P61769; Nucleus . Isoform 1: Nucleus speckle . Isoform 4: Nucleus, nucleoplasm : P19544
• Total number of polymer chains: 6
• Total formula weight: 89789.81

Authors

Borbulevych, O.Y.,Baker, B.M. (deposition date: 2010-05-10, release date: 2010-08-18, Last modification date: 2023-09-06)

• Primary citation: Borbulevych, O.Y.,Do, P.,Baker, B.M.; Structures of native and affinity-enhanced WT1 epitopes bound to HLA-A*0201: Implications for WT1-based cancer therapeutics.; Mol.Immunol., 47:2519-2524, 2010; PubMed: 20619457; DOI: 10.1016/j.molimm.2010.06.005

Experimental method

X-RAY DIFFRACTION (1.89 Å)