3MRV

Glycogen phosphorylase complexed with 3-hydroxybenzaldehyde-4-(beta-D-glucopyranosyl) thiosemicarbazone

Summary for 3MRV

Entry DOI	10.2210/pdb3mrv/pdb
Related	3MQF 3MRT 3MRX 3MS2 3MS4 3MS7 3MSC 3MT7 3MT8 3MT9 3MTA 3MTB 3MTD
Descriptor	Glycogen phosphorylase, muscle form, N-({(2Z)-2-[(3-hydroxyphenyl)methylidene]hydrazino}carbonothioyl)-beta-D-glucopyranosylamine, DIMETHYL SULFOXIDE, ... (4 entities in total)
Functional Keywords	glycogenolysis, type 2 diabetes, transferase-transferase inhibitor complex, transferase/transferase inhibitor
Biological source	Oryctolagus cuniculus (European rabbit,Japanese white rabbit,domestic rabbit,rabbits)
Total number of polymer chains	1
Total formula weight	98312.22
Authors	Alexacou, K.-M. (deposition date: 2010-04-29, release date: 2011-01-05, Last modification date: 2023-11-22)
Primary citation	Alexacou, K.M.,Tenchiu Deleanu, A.C.,Chrysina, E.D.,Charavgi, M.D.,Kostas, I.D.,Zographos, S.E.,Oikonomakos, N.G.,Leonidas, D.D. The binding of beta-D-glucopyranosyl-thiosemicarbazone derivatives to glycogen phosphorylase: a new class of inhibitors Bioorg.Med.Chem., 18:7911-7922, 2010 Cited by PubMed: 20947361 DOI: 10.1016/j.bmc.2010.09.039 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.94 Å)

Structure validation