3MPT
Crystal structure of P38 kinase in complex with a pyrrole-2-carboxamide inhibitor
Summary for 3MPT
Entry DOI | 10.2210/pdb3mpt/pdb |
Descriptor | Mitogen-activated protein kinase 14, N-(furan-2-ylmethyl)-4-[(2-methylphenyl)carbonyl]-1H-pyrrole-2-carboxamide, GLYCEROL, ... (4 entities in total) |
Functional Keywords | p38, serine/threonine protein kinase, map kinase, pyrrole-2-carboxamides, inhibitor, transferase-transferase inhibiator complex, transferase-transferase inhibitor complex, transferase/transferase inhibitor |
Biological source | Homo sapiens (human) |
Cellular location | Cytoplasm (By similarity): Q16539 |
Total number of polymer chains | 1 |
Total formula weight | 43235.35 |
Authors | Somers, D.O. (deposition date: 2010-04-27, release date: 2010-07-07, Last modification date: 2023-09-06) |
Primary citation | Down, K.,Bamborough, P.,Alder, C.,Campbell, A.,Christopher, J.A.,Gerelle, M.,Ludbrook, S.,Mallett, D.,Mellor, G.,Miller, D.D.,Pearson, R.,Ray, K.,Solanke, Y.,Somers, D. The discovery and initial optimisation of pyrrole-2-carboxamides as inhibitors of p38alpha MAP kinase. Bioorg.Med.Chem.Lett., 20:3936-3940, 2010 Cited by PubMed: 20570148DOI: 10.1016/j.bmcl.2010.05.011 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.89 Å) |
Structure validation
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