3M8Q
HIV-1 RT with AMINOPYRIMIDINE NNRTI
Summary for 3M8Q
Entry DOI | 10.2210/pdb3m8q/pdb |
Related | 3M8P |
Descriptor | Reverse transcriptase/ribonuclease H, p51 RT, 3,5-dimethyl-4-{[2-({1-[4-(methylsulfonyl)benzyl]piperidin-4-yl}amino)pyrimidin-4-yl]oxy}benzonitrile, ... (4 entities in total) |
Functional Keywords | hiv, rt, reverse transcriptase ribonuclease h, transferase rna-directed dna polymerase, nucleotidyltransferase, hydrolase, transferase |
Biological source | Human immunodeficiency virus type 1 (HIV-1) More |
Cellular location | Matrix protein p17: Virion (Potential). Capsid protein p24: Virion (Potential). Nucleocapsid protein p7: Virion (Potential). Reverse transcriptase/ribonuclease H: Virion (Potential). Integrase: Virion (Potential): P04585 P04585 |
Total number of polymer chains | 2 |
Total formula weight | 116600.77 |
Authors | Harris, S.F.,Villasenor, A. (deposition date: 2010-03-18, release date: 2010-05-19, Last modification date: 2024-02-21) |
Primary citation | Kertesz, D.J.,Brotherton-Pleiss, C.,Yang, M.,Wang, Z.,Lin, X.,Qiu, Z.,Hirschfeld, D.R.,Gleason, S.,Mirzadegan, T.,Dunten, P.W.,Harris, S.F.,Villasenor, A.G.,Hang, J.Q.,Heilek, G.M.,Klumpp, K. Discovery of piperidin-4-yl-aminopyrimidines as HIV-1 reverse transcriptase inhibitors. N-benzyl derivatives with broad potency against resistant mutant viruses. Bioorg.Med.Chem.Lett., 20:4215-4218, 2010 Cited by PubMed: 20538456DOI: 10.1016/j.bmcl.2010.05.040 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.7 Å) |
Structure validation
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