3M6S

Crystal structure of H1N1pdm Hemagglutinin

Summary for 3M6S

• Entry DOI: 10.2210/pdb3m6s/pdb
• Descriptor: Hemagglutinin, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, alpha-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... (5 entities in total)
• Functional Keywords: influenza virus, hemagglutinin, pandemic, envelope protein, fusion protein, host cell membrane, host membrane, membrane, transmembrane, virion, viral protein
• Biological source: Influenza A virus (A/Darwin/2001/2009(H1N1)); More
• Total number of polymer chains: 12
• Total formula weight: 347690.97

Authors

Yang, H.,Carney, P.J.,Stevens, J. (deposition date: 2010-03-16, release date: 2010-03-31, Last modification date: 2024-11-27)

Primary citation

Yang, H.,Carney, P.,Stevens, J.
Structure and Receptor binding properties of a pandemic H1N1 virus hemagglutinin
PLoS Curr, :RRN1152-RRN1152, 2010

PubMed Abstract: The 3D-structure of the major surface viral antigen from the recent H1N1 pandemic influenza virus (A/Darwin/2001/2009) was determined to 2.8 Å resolution. The structure was used to analyze changes in the HA that have emerged during the first 11 months of the pandemic and have raised public health concerns. Receptor binding properties of this protein reveals a strict preference for human-type receptors.

PubMed: 20352039

Experimental method

X-RAY DIFFRACTION (2.8 Å)