3LW8

Shigella IpgB2 in complex with human RhoA, GDP and Mg2+ (complex A)

Summary for 3LW8

Entry DOI	10.2210/pdb3lw8/pdb
Related	3LWN 3LXR 3LYQ
Descriptor	Transforming protein RhoA, IpgB2, GUANOSINE-5'-DIPHOSPHATE, ... (5 entities in total)
Functional Keywords	ipgb2, rhoa, gtpase, gef, gef-gtpase-complex, wxxxe, ttss effector protein, bacterial gef, cytoskeleton dynamics, signaling protein-rhoa-binding protein complex, signaling protein/rhoa-binding protein
Biological source	Homo sapiens (human) More
Cellular location	Cell membrane; Lipid-anchor; Cytoplasmic side: P61586
Total number of polymer chains	8
Total formula weight	172604.84
Authors	Klink, B.U.,Barden, S.,Heidler, T.V.,Borchers, C.,Ladwein, M.,Stradal, T.E.B.,Rottner, K.,Heinz, D.W. (deposition date: 2010-02-23, release date: 2010-03-31, Last modification date: 2023-11-01)
Primary citation	Klink, B.U.,Barden, S.,Heidler, T.V.,Borchers, C.,Ladwein, M.,Stradal, T.E.B.,Rottner, K.,Heinz, D.W. Structure of Shigella IPGB2 in complex with human RhoA: Implications for the mechanism of bacterial GEF-mimicry J.Biol.Chem., 285:17197-17208, 2010 Cited by PubMed: 20363740 DOI: 10.1074/jbc.M110.107953 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.85 Å)

Structure validation