3LPJ

Structure of BACE Bound to SCH743641

Summary for 3LPJ

Entry DOI	10.2210/pdb3lpj/pdb
Related	3LPI 3LPK
Descriptor	Beta-secretase 1, L(+)-TARTARIC ACID, N'-[(1S,2S)-2-[(2R)-4-benzylpiperazin-2-yl]-1-(3,5-difluorobenzyl)-2-hydroxyethyl]-5-methyl-N,N-dipropylbenzene-1,3-dicarboxamide, ... (4 entities in total)
Functional Keywords	alzheimer's, aspartyl protease, hydrolase
Biological source	Homo sapiens (human)
Cellular location	Membrane; Single-pass type I membrane protein: P56817
Total number of polymer chains	2
Total formula weight	101954.65
Authors	Strickland, C.,Cumming, J. (deposition date: 2010-02-05, release date: 2010-04-14, Last modification date: 2017-11-01)
Primary citation	Cumming, J.,Babu, S.,Huang, Y.,Carrol, C.,Chen, X.,Favreau, L.,Greenlee, W.,Guo, T.,Kennedy, M.,Kuvelkar, R.,Le, T.,Li, G.,McHugh, N.,Orth, P.,Ozgur, L.,Parker, E.,Saionz, K.,Stamford, A.,Strickland, C.,Tadesse, D.,Voigt, J.,Zhang, L.,Zhang, Q. Piperazine sulfonamide BACE1 inhibitors: design, synthesis, and in vivo characterization. Bioorg.Med.Chem.Lett., 20:2837-2842, 2010 Cited by PubMed: 20347593 DOI: 10.1016/j.bmcl.2010.03.050 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.79 Å)

Structure validation