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3LPI

Structure of BACE Bound to SCH745132

Summary for 3LPI
Entry DOI10.2210/pdb3lpi/pdb
Related3LPJ 3LPK
DescriptorBeta-secretase 1, L(+)-TARTARIC ACID, N'-{(1S,2S)-1-(3,5-difluorobenzyl)-2-hydroxy-2-[(2R)-4-(phenylsulfonyl)piperazin-2-yl]ethyl}-5-methyl-N,N-dipropylbenzene-1,3-dicarboxamide, ... (4 entities in total)
Functional Keywordsalzheimer's, aspartyl protease, hydrolase
Biological sourceHomo sapiens (human)
Cellular locationMembrane; Single-pass type I membrane protein: P56817
Total number of polymer chains2
Total formula weight102054.72
Authors
Strickland, C.,Cumming, J. (deposition date: 2010-02-05, release date: 2010-04-14, Last modification date: 2017-11-01)
Primary citationCumming, J.,Babu, S.,Huang, Y.,Carrol, C.,Chen, X.,Favreau, L.,Greenlee, W.,Guo, T.,Kennedy, M.,Kuvelkar, R.,Le, T.,Li, G.,McHugh, N.,Orth, P.,Ozgur, L.,Parker, E.,Saionz, K.,Stamford, A.,Strickland, C.,Tadesse, D.,Voigt, J.,Zhang, L.,Zhang, Q.
Piperazine sulfonamide BACE1 inhibitors: design, synthesis, and in vivo characterization.
Bioorg.Med.Chem.Lett., 20:2837-2842, 2010
Cited by
PubMed: 20347593
DOI: 10.1016/j.bmcl.2010.03.050
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (2.05 Å)
Structure validation

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