3LON
HCV NS3-4a protease domain with ketoamide inhibitor narlaprevir
Summary for 3LON
Entry DOI | 10.2210/pdb3lon/pdb |
Descriptor | Genome polyprotein, KK-NS4a(21-39)-KK, ZINC ION, ... (6 entities in total) |
Functional Keywords | hepatitis c virus, ns3 protease domain, serine protease, macrocyclic ketoamide inhibitor, hydrolase, atp-binding, capsid protein, envelope protein, helicase, host membrane, membrane, nucleotide-binding, rna replication, transmembrane, virion, viral protein, viral protein-inhibitor complex, viral protein/inhibitor |
Biological source | Hepatitis C virus subtype 1a More |
Total number of polymer chains | 4 |
Total formula weight | 48173.46 |
Authors | Prongay, A.J. (deposition date: 2010-02-04, release date: 2011-01-19, Last modification date: 2024-04-03) |
Primary citation | Arasappan, A.,Bennett, F.,Bogen, S.L.,Blackman, M.,Chen, K.,Hendrata, S.,Huang, Y.,Huelgas, R.M.,Nair, L.,Padilla, A.I.,Pan, W.,Pike, R.,Pinto, P.,Ruan, S.,Sannigrahi, M.,Velaquez, F.,Vibulbhan, B.,Wu, W.,Yang, W.,Saksena, A.K.,Girijavallabhan, V.,Shih, N.Y.,Kong, J.,Meng, T.,Jin, Y.,Wong, J.,McNamara, P.,Prongay, A.,Madison, V.,Piwinski, J.J.,Cheng, K.C.,Morrison, R.,Malcolm, B.,Tong, X.,Ralston, R.,Njoroge, F.G. Candidate selection and preclinical evaluation culminating in the discovery of Narlaprevir (SCH 900518): A potent, selective and orally efficacious second generation HCV NS3 serine protease inhibitor To be Published, |
Experimental method | X-RAY DIFFRACTION (2.2 Å) |
Structure validation
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