3LKY

Monomeric Griffithsin with a Single Gly-Ser Insertion

Summary for 3LKY

Entry DOI	10.2210/pdb3lky/pdb
Related	2gty 2guc 2gud 2gue 2gux 2hyq 2hyr 2nu5 2nuo 3LL0 3LL1 3LL2
Descriptor	Griffithsin, GLYCEROL, 1,2-ETHANEDIOL, ... (5 entities in total)
Functional Keywords	lectin, sugar-binding, anti-hiv, high mannose, man9, gp120, gp41, jacalin-related, mannose-binding, sugar binding protein
Biological source	Griffithsia (Red alga)
Total number of polymer chains	1
Total formula weight	13533.54
Authors	Moulaei, T.,Wlodawer, A. (deposition date: 2010-01-28, release date: 2010-10-06, Last modification date: 2023-09-06)
Primary citation	Moulaei, T.,Shenoy, S.R.,Giomarelli, B.,Thomas, C.,McMahon, J.B.,Dauter, Z.,O'Keefe, B.R.,Wlodawer, A. Monomerization of viral entry inhibitor griffithsin elucidates the relationship between multivalent binding to carbohydrates and anti-HIV activity. Structure, 18:1104-1115, 2010 Cited by PubMed: 20826337 DOI: 10.1016/j.str.2010.05.016 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.11 Å)

Structure validation