3LGG

Crystal structure of human adenosine deaminase growth factor, adenosine deaminase type 2 (ADA2) complexed with transition state analogue, coformycin

Summary for 3LGG

• Entry DOI: 10.2210/pdb3lgg/pdb
• Related: 3LGD
• Descriptor: Adenosine deaminase CECR1, 2-acetamido-2-deoxy-beta-D-glucopyranose, ZINC ION, ... (5 entities in total)
• Functional Keywords: tim barrel, dimerization and receptor binding domains, glycoprotein, hydrolase, growth factor, secreted
• Biological source: Homo sapiens (human)
• Cellular location: Secreted: Q9NZK5
• Total number of polymer chains: 2
• Total formula weight: 120125.19

Authors

Zavialov, A.V. (deposition date: 2010-01-20, release date: 2010-02-09, Last modification date: 2020-07-29)

• Primary citation: Zavialov, A.V.,Yu, X.,Spillmann, D.,Lauvau, G.,Zavialov, A.V.; Structural basis for the growth factor activity of human adenosine deaminase ADA2.; J.Biol.Chem., 285:12367-12377, 2010; PubMed: 20147294; DOI: 10.1074/jbc.M109.083527

Experimental method

X-RAY DIFFRACTION (2.5 Å)