3LGG

Crystal structure of human adenosine deaminase growth factor, adenosine deaminase type 2 (ADA2) complexed with transition state analogue, coformycin

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B (A, B)	Adenosine deaminase CECR1	polymer	508	59049.3	2	UniProt (Q9NZK5) Pfam (PF08451) Pfam (PF00962)	Homo sapiens (human)	Cat eye syndrome critical region protein 1
2	C, D, E, H, I... (A, B)	2-acetamido-2-deoxy-beta-D-glucopyranose	non-polymer		221.2	6	Chemie (NAG)
3	F, K (A, B)	ZINC ION	non-polymer		65.4	2	Chemie (ZN)
4	G, L (A, B)	(8R)-3-beta-D-ribofuranosyl-3,6,7,8-tetrahydroimidazo[4,5-d][1,3]diazepin-8-ol	non-polymer		284.3	2	Chemie (CFE)
5	M, N (A, B)	water	water		18.0	244	Chemie (HOH)

Sequence modifications

A, B: 3 - 485 (UniProt: Q9NZK5)

PDB	External Database	Details
Gly 1	-	expression tag
Gly 2	-	expression tag
Gly 486	-	expression tag
Ser 487	-	expression tag
Leu 488	-	expression tag
His 489	-	expression tag
His 490	-	expression tag
Ile 491	-	expression tag
Leu 492	-	expression tag
Asp 493	-	expression tag
Ala 494	-	expression tag
Gln 495	-	expression tag
Lys 496	-	expression tag
Met 497	-	expression tag
Val 498	-	expression tag
Trp 499	-	expression tag
Asn 500	-	expression tag
His 501	-	expression tag
Arg 502	-	expression tag
His 503	-	expression tag
His 504	-	expression tag
His 505	-	expression tag
His 506	-	expression tag
His 507	-	expression tag
His 508	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	118098.6
Non-Polymers*	Number of molecules	10
	Total formula weight	2026.6
All*	Total formula weight	120125.2

*Water molecules are not included.