3LG4

Staphylococcus aureus V31Y, F92I mutant dihydrofolate reductase complexed with NADPH and 5-[(3S)-3-(5-methoxy-2',6'-dimethylbiphenyl-3-yl)but-1-yn-1-yl]-6-methylpyrimidine-2,4-diamine

Summary for 3LG4

Entry DOI	10.2210/pdb3lg4/pdb
Related	3F0Q 3F0V
Descriptor	Dihydrofolate reductase, NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, 5-[(3S)-3-(5-methoxy-2',6'-dimethylbiphenyl-3-yl)but-1-yn-1-yl]-6-methylpyrimidine-2,4-diamine (3 entities in total)
Functional Keywords	oxidoreductase, nadp, one-carbon metabolism
Biological source	Staphylococcus aureus
Total number of polymer chains	2
Total formula weight	41312.27
Authors	Frey, K.M.,Anderson, A.C. (deposition date: 2010-07-08, release date: 2010-07-28, Last modification date: 2023-09-06)
Primary citation	Frey, K.M.,Georgiev, I.,Donald, B.R.,Anderson, A.C. Predicting resistance mutations using protein design algorithms. Proc.Natl.Acad.Sci.USA, 107:13707-13712, 2010 Cited by PubMed: 20643959 DOI: 10.1073/pnas.1002162107 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (3.15 Å)

Structure validation