3LDX
Discovery and Clinical Evaluation of RWJ-671818, a Thrombin Inhibitor with an Oxyguanidine P1 Motif
Summary for 3LDX
Entry DOI | 10.2210/pdb3ldx/pdb |
Descriptor | Thrombin light chain, Thrombin heavy chain, Hirudin variant-1, ... (5 entities in total) |
Functional Keywords | blood clotting, hydrolase-hydrolase inhibitor complex, blood coagulation, serine protease, hydrolase/hydrolase inhibitor |
Biological source | Homo sapiens (human) More |
Cellular location | Secreted, extracellular space: P00734 P00734 Secreted: P01050 |
Total number of polymer chains | 3 |
Total formula weight | 35711.63 |
Authors | Spurlino, J.C. (deposition date: 2010-01-13, release date: 2011-08-10, Last modification date: 2017-07-19) |
Primary citation | Spurlino, J.C. Discovery and Clinical Evaluation of RWJ-671818, a Thrombin Inhibitor with an Oxyguanidine P1 Motif To be Published, |
Experimental method | X-RAY DIFFRACTION (2.246 Å) |
Structure validation
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