3LDX
Discovery and Clinical Evaluation of RWJ-671818, a Thrombin Inhibitor with an Oxyguanidine P1 Motif
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (L) | Thrombin light chain | polymer | 36 | 4096.5 | 1 | UniProt (P00734) Pfam (PF09396) | Homo sapiens (human) | Coagulation factor II |
| 2 | B (H) | Thrombin heavy chain | polymer | 259 | 29780.2 | 1 | UniProt (P00734) Pfam (PF00089) | Homo sapiens (human) | Coagulation factor II |
| 3 | C (I) | Hirudin variant-1 | polymer | 11 | 1411.5 | 1 | UniProt (P01050) | Hirudo medicinalis | Hirudin-1, Hirudin-I, Lepirudin |
| 4 | D (H) | N-[2-(carbamimidamidooxy)ethyl]-2-{3-[(2,2-difluoro-2-phenylethyl)amino]-6-methyl-2-oxopyrazin-1(2H)-yl}acetamide | non-polymer | 423.4 | 1 | Chemie (NLI) | |||
| 5 | E, F (L, H) | water | water | 18.0 | 46 | Chemie (HOH) |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 3 |
| Total formula weight | 35288.2 | |
| Non-Polymers* | Number of molecules | 1 |
| Total formula weight | 423.4 | |
| All* | Total formula weight | 35711.6 |
