3LDI

Crystal structure of aprotinin in complex with sucrose octasulfate: unusual interactions and implication for heparin binding

Summary for 3LDI

Entry DOI	10.2210/pdb3ldi/pdb
Related	3LDJ 3LDM
Descriptor	Pancreatic trypsin inhibitor, SULFATE ION, MERCURY (II) ION, ... (5 entities in total)
Functional Keywords	aprotinin, sucrose octasulfate, disulfide bond, protease inhibitor, secreted, serine protease inhibitor, hydrolase inhibitor
Biological source	Bos taurus (Bovine)
Cellular location	Secreted: P00974
Total number of polymer chains	5
Total formula weight	35554.11
Authors	Yang, I.S.,Kim, T.G.,Park, B.S.,Kim, K.H. (deposition date: 2010-01-13, release date: 2010-06-23, Last modification date: 2014-02-12)
Primary citation	Yang, I.S.,Kim, T.G.,Park, B.S.,Cho, K.J.,Lee, J.-H.,Park, Y.,Kim, K.H. Crystal structures of aprotinin and its complex with sucrose octasulfate reveal multiple modes of interactions with implications for heparin binding Biochem.Biophys.Res.Commun., 397:429-435, 2010 Cited by PubMed: 20529698 DOI: 10.1016/j.bbrc.2010.05.113 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.2 Å)

Structure validation